Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition

@inproceedings{RenaultMihara2011BeneficialCO,
  title={Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition},
  author={Francois Renault-Mihara and Hiroyuki Katoh and Takeshi Ikegami and Akio Iwanami and Masahiko Mukaino and Akimasa Yasuda and Satoshi Nori and Yo Mabuchi and Hirobumi Tada and Shinsuke Shibata and Ken Saito and Masayuki Matsushita and Kozo Kaibuchi and Seiji Okada and Yoshiaki Toyama and Masaya Nakamura and Hideyuki Okano},
  booktitle={EMBO molecular medicine},
  year={2011}
}
The migratory response of astrocytes is essential for restricting inflammation and preserving tissue function after spinal cord injury (SCI), but the mechanisms involved are poorly understood. Here, we observed stimulation of in vitro astrocyte migration by the new potent glycogen synthase kinase-3 (GSK-3) inhibitor Ro3303544 and investigated the effect of Ro3303544 administration for 5 days following SCI in mice. This treatment resulted in accelerated migration of reactive astrocytes to… CONTINUE READING

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STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 16 Excerpts
Highly Influenced

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 1 Excerpt

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