Beneficial circulatory effect of L-arginine.

@article{Nakaki1994BeneficialCE,
  title={Beneficial circulatory effect of L-arginine.},
  author={Toshio Nakaki and Ryuichi Kato},
  journal={Japanese journal of pharmacology},
  year={1994},
  volume={66 2},
  pages={
          167-71
        }
}
L-Arginine is an essential amino acid for infants and growing children. This amino acid is a substrate for at least five enzymes identified in mammals, including arginase, arginine-glycine transaminase, kyotorphine synthase, nitric oxide synthase (NOS) and arginine decarboxylase. L-Arginine exerts antihypertensive and antiproliferative effects on vascular smooth muscles. NOS and arginine decarboxylase appear to be important for the effect of L-arginine on the circulatory system, since each… 
[The arginine paradox].
TLDR
The arginine paradox refers to the phenomenon that exogenous L-arginine causes NO-mediated biological effects despite the fact that nitric oxide synthases (NOS) are theoretically saturated with the substrate L- arginine.
Arginine: Clinical potential of a semi-essential amino acid..
  • J. Appleton
  • Medicine, Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 2002
TLDR
Because of arginine's NO-stimulating effects, it can be utilized in therapeutic regimens for angina pectoris, congestive heart failure, hypertension, coronary heart disease, preeclampsia, intermittent claudication, and erectile dysfunction.
Blockade of hepatic nitric oxide synthase causes insulin resistance.
TLDR
The results suggest that blockade of NOS causes peripheral insulin resistance secondary to blockade of the hepatic parasympathetic reflex release of hepatic insulin-sensitizing substance in response to insulin.
Mechanisms Involved in Protection Afforded by l-Arginine in Ibuprofen-Induced Gastric Damage: Role of Nitric Oxide and Prostaglandins
TLDR
The measurement of mucosal PGE2 content confirmed that biosynthesis of the eicosanoid is maintained by l-arg for over 90 min after IBP, while a total inhibition was observed 6 hr later, which could be explained by the different period after drug administration.
Blockade of hepatic nitric oxide synthase causes insulin resistance.
  • P. Sadri, W. Lautt
  • Medicine, Biology
    American journal of physiology. Gastrointestinal and liver physiology
  • 1999
TLDR
The results suggest that blockade of NOS causes peripheral insulin resistance secondary to blockade of the hepatic parasympathetic reflex release of hepatic insulin-sensitizing substance in response to insulin.
Competitive inhibition of nitric oxide synthase by p-aminobenzamidine, a serine proteinase inhibitor.
TLDR
This work investigated the interaction of p-aminobenzamidine with mouse brain nitric oxide synthase (NOS), which uses L-arginine as the substrate for generating NO and L-citrulline, and found p-AminobenzAMidine affects the NO production and the trypsin-like serine proteinase action.
The effect of L-arginine on intraocular pressure in the human eye
TLDR
These findings demonstrated that L-arginine lowers intraocular pressure mainly through the formation of NO, and significantly elevated the level of nitrite in the aqueous humor compared with the controls.
Effects of dietary l-arginine on the reactivity of canine coronary arteries
TLDR
The results suggest that dietary supplementation with l-arginine modifies reactivity of endothelium and smooth muscle by at least two mechanisms: one associated with activation of potassium channels and the other with receptor-coupled release of nitric oxide.
Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels.
TLDR
It is concluded that oral supplementation with L-ARG 20 g/day for 28 days does not affect endothelial function in normal healthy adults, possibly because the dose given was inadequate or because chronic oral administration leads to dissipation of arginine to other pathways, as evidenced by the change in total amino acid profile but not L- ARG plasma concentration.
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References

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L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
TLDR
In vitro hypothesis that L-arginine is a precursor for EDRF synthesis, whose availability may become rate limiting during pulmonary hypertension is supported, supported by in vitro data from 16 intact newborn lambs.
Effect of systemic L-arginine administration on hemodynamics and nitric oxide release in man.
TLDR
Evidence is provided for the first time that systemically administered L-arginine releases NO in man and slightly changed several hormones, but all values were within normal ranges.
l‐ARGININE INFUSION INDUCES HYPOTENSION AND DIURESIS/NATRIURESIS WITH CONCOMITANT INCREASED URINARY EXCRETION OF NITRITE/NITRATE AND CYCLIC GMP IN HUMANS
TLDR
The present study examined the effects of l‐arginine (l‐Arg), a substrate for NO, on the responses of mean blood pressure (MBP) and heart rate (HR) and plasma concentrations of cGMP, atrial natriuretic factor (ANF) and nitrite/nitrate (NOx) and urinary flow in eight normal male subjects.
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TLDR
The results suggest that exogenous L-arginine produces a vasodilatory effect by increasing NO production and that L- arginine, or released NO, modulates the release of neuroendocrine hormones in hypertensive subjects.
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TLDR
Observations strongly suggest that, in the intact guinea pig pulmonary artery, EDRF originates from enzymatic action on the guanido nitrogen(s) of an endogenous pool of arginine, strikingly similar to the origin of reactive nitrogen intermediates in activated macrophages.
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TLDR
It is suggested that intravenously administered L-arginine produces an elevation of renal blood flow, which may be mediated by facilitation of endogenous acetylcholine-induced release of endothelium-derived relaxing factor and vasodilatory prostaglandins.
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TLDR
The findings indicate that L-NMA acts centrally by an ARG-reversible mechanism in the anesthetized rat to stimulate sympathetic nerve activity and suggest that one such function would be the central regulation of sympathetic outflow and hence, BP.
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TLDR
This is the first study to demonstrate that supplementation of dietary L-arginine, the EDRF precursor, improves endothelium-dependent vasorelaxation and is associated with a reduction in atherogenesis.
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