Beneficial cardiovascular pleiotropic effects of statins.

  title={Beneficial cardiovascular pleiotropic effects of statins.},
  author={Jean Davignon},
  volume={109 23 Suppl 1},
Pleiotropic effects of a drug are actions other than those for which the agent was specifically developed. These effects may be related or unrelated to the primary mechanism of action of the drug, and they are usually unanticipated. Pleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), beneficial. Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric… CONTINUE READING


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