Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.


Obesity is associated with increased diastolic stiffness and myocardial steatosis and dysfunction. The impact of aging on the protective effects of caloric restriction (CR) is not clear. We studied 2-month (younger) and 6-7-month (older)-old ob/ob mice and age-matched C57BL/6J controls (WT). Ob/ob mice were assigned to diet ad libitum or CR for 4 weeks. We… (More)
DOI: 10.1007/s12265-013-9453-4


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