Beneficial and harmful effects of L-arginine on renal ischaemia.

  title={Beneficial and harmful effects of L-arginine on renal ischaemia.},
  author={L A Tom{\'e} and Luis Yu and Isac de Castro and Simone Becho Campos and Ant{\^o}nio Carlos Seguro},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={14 5},
BACKGROUND The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood. L-Arginine (L-arg) is protective against different ARF models, while L-arg addition in isolated proximal tubules enhances hypoxia/reoxygenation (H/R) injury. The aim of this study was to evaluate the effects of L-arg on renal ischaemia. METHODS In in vivo studies, Wistar rats were subjected to 60 min renal artery clamping, and renal function was evaluated 2 and 15 days after ischaemia. Four… CONTINUE READING


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