Beneficial actions of microbiota‐derived tryptophan metabolites

  title={Beneficial actions of microbiota‐derived tryptophan metabolites},
  author={James J. Galligan},
  journal={Neurogastroenterology \& Motility},
  • J. Galligan
  • Published 1 February 2018
  • Biology
  • Neurogastroenterology & Motility
Tryptophan is an important dietary amino acid and it is the precursor for 5‐hydroxytryptamine synthesis in the nervous system and by enterochromaffin cells in the gut mucosa. Tryptophan is also metabolized by enzymes in the gut mucosa and also by enzymes produced by the gut microbiome. Diet and the microbiome can contribute to metabolic disease in part by causing intestinal inflammation and increased permeability. In this issue of Neurogastroenterology and Motility, Jennis et al. test the… 

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