Beneficial Effects of Canagliflozin in Combination with Pioglitazone on Insulin Sensitivity in Rodent Models of Obese Type 2 Diabetes

@inproceedings{Watanabe2015BeneficialEO,
  title={Beneficial Effects of Canagliflozin in Combination with Pioglitazone on Insulin Sensitivity in Rodent Models of Obese Type 2 Diabetes},
  author={Yoshinori Watanabe and Keiko Nakayama and Nobuhiko Taniuchi and Yasushi Horai and Chiaki Kuriyama and Kiichiro Ueta and Kenji Arakawa and Takaaki Senbonmatsu and Masaharu Shiotani},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Despite its insulin sensitizing effects, pioglitazone may induce weight gain leading to an increased risk of development of insulin resistance. A novel sodium glucose co-transporter 2 (SGLT2) inhibitor, canagliflozin, provides not only glycemic control but also body weight reduction through an insulin-independent mechanism. The aim of this study was to investigate the combined effects of these agents on body weight control and insulin sensitivity. METHODS Effects of combination… CONTINUE READING

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