Beneficial Effect of Salbutamol on Cardiac Function in Severe Congestive Cardiomyopathy

Abstract

The effects of Salbutamol (a "selective" beta2 agonist) were studied in 12 patients with congestive cardiomyopathy in a dose of 0.5 ,ug/min/kg. In Study A (n = 6), pressures and cardiac index (CI) were measured at rest and during supine exercise. Study B (n = 6) was specifically designed to observe the effects of Salbutamol on the indices of left ventricular performance and diastolic pressure-volume relationships. The results of Study A revealed Salbutamol infusion significantly (P < 0.001) increases CI from 1.8-3.9 I/min/M2 in the resting state; the exercise CI improved from 3 to 4.5 I/min/m' (P < 0.005); there was a marked decrease in left ventricular end-diastolic pressure at rest from 27-13 mm Hg (P < 0.001) and during exercise from 39-20 mm Hg (P < 0.001). There was no significant change in heart rate and blood

Cite this paper

@inproceedings{GOODWIN2005BeneficialEO, title={Beneficial Effect of Salbutamol on Cardiac Function in Severe Congestive Cardiomyopathy}, author={JESSE F . GOODWIN}, year={2005} }