Beneficial Effect of Oral Bisphosphonate Treatment on Bone Loss Induced by Chronic Administration of Furosemide without Alteration of Its Administration and Urinary Calcium Loss

@inproceedings{Kubota2006BeneficialEO,
  title={Beneficial Effect of Oral Bisphosphonate Treatment on Bone Loss Induced by
Chronic Administration of Furosemide without Alteration of Its Administration and Urinary
Calcium Loss},
  author={Takuo Kubota and Noriyuki Namba and Shunji Kurotobi and Shigetoyo Kogaki and Haruhiko Hirai and Taichi Kitaoka and Shigeo Nakajima and Keiichi Ozono},
  booktitle={Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology},
  year={2006}
}
Bisphosphonate is widely used to treat patients with primary and secondary osteoporosis. The chronic administration of furosemide is considered a risk factor for osteoporosis mainly due to the increased urinary excretion of calcium, leading to a long-term negative balance of calcium. We describe two patients with mild heart failure who took furosemide for more than 5 yr and developed hyperparathyroidism and lumbago associated with low bone mineral density. Their serum levels of intact… CONTINUE READING