Beneficial Effect of Insulin Treatment on Islet Transplantation Outcomes in Akita Mice

Abstract

Islet transplantation is a promising potential therapy for patients with type 1 diabetes. The outcome of islet transplantation depends on the transplantation of a sufficient amount of β-cell mass. However, the initial loss of islets after transplantation is problematic. We hypothesized the hyperglycemic status of the recipient may negatively affect graft… (More)
DOI: 10.1371/journal.pone.0095451

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