Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link.

  title={Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link.},
  author={Stacia M Rink and Ruth Lipman and Stephen C. Alley and Paul B. Hopkins and Maria Tomasz},
  journal={Chemical research in toxicology},
  volume={9 2},
Mitomycin C (MC) forms interstrand and intrastrand cross-link adducts and monoalkylation products (monoadducts) with DNA. Each of the three types of adducts was incorporated site-specifically into both a 15-mer and a 21-mer oligodeoxyribonucleotide duplex. The adduct-containing duplexes were 32P-phosphorylated and ligated to form multimers, which were then analyzed for anomalous electrophoretic mobility by nondenaturing polyacrylamide gel electrophoresis, using the method of Koo and Crothers… CONTINUE READING
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The Mitomycins: Natural Cross-linkers of DNA

  • M. Tomasz
  • 1994

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