Bending Gradients: How the Intestinal Stem Cell Gets Its Home

  title={Bending Gradients: How the Intestinal Stem Cell Gets Its Home},
  author={Amy E Shyer and Tyler R. Huycke and Changhee Lee and Lakshminarayanan Mahadevan and Clifford J Tabin},
We address the mechanism by which adult intestinal stem cells (ISCs) become localized to the base of each villus during embryonic development. We find that, early in gut development, proliferating progenitors expressing ISC markers are evenly distributed throughout the epithelium, in both the chick and mouse. However, as the villi form, the putative stem cells become restricted to the base of the villi. This shift in the localization is driven by mechanically influenced reciprocal signaling… CONTINUE READING
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