Bendamustine in B-Cell Malignancies: The New 46-Year-Old Kid on the Block.


On March 20, 2008, bendamustine HCl (Treanda, Cephalon, Inc.) was approved by the U.S. Food and Drug Administration (FDA) for treatment of chronic lymphocytic leukemia (CLL). This approval was based on a randomized, multicenter trial comparing the test drug (n = 162) to chlorambucil (n = 157) as a first line treatment (1). Overall response rates (ORR) were… (More)


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