Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial.

@article{Knauf2012BendamustineCW,
  title={Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial.},
  author={Wolfgang Ulrich Knauf and Toshko J. Lissitchkov and Ali Aldaoud and Anna Marina Liberati and Javier Loscertales and Raoul Herbrecht and Gunnar Juliusson and Gerhard Postner and Liana Gercheva and Stefan G Goranov and Martin Becker and H. Fricke and Françoise Huguet and Ilaria Del Giudice and Peter T. Klein and Karlheinz Merkle and Marco Montillo},
  journal={British journal of haematology},
  year={2012},
  volume={159 1},
  pages={67-77}
}
The efficacy of bendamustine versus chlorambucil in a phase III trial of previously untreated patients with Binet stage B/C chronic lymphocytic leukaemia (CLL) was re-evaluated after a median observation time of 54 months in May 2010. Overall survival (OS) was analysed for the first time. At follow-up, investigator-assessed complete response (CR) rate (21·0% vs 10·8%), median progression-free survival (21·2 vs 8·8 months; P < 0·0001; hazard ratio 2·83) and time to next treatment (31·7 vs 10·1… CONTINUE READING
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