Benchmarks PCR Genotyping of oim Mutant Mice

  • Published 1999


A protocol has been developed to distinguish between wild-type, heterozygous and homozygous oim mutant mice. Oim mice (The Jackson Laboratory, Bar Harbor, ME, USA) have a singlebase deletion in their proα2(I) collagen gene (cola-2 gene). This mutation changes the reading frame at the 3′ end of the mRNA causing synthesis of an altered C-propeptide that… (More)

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