Benchmarking ortholog identification methods using functional genomics data

  title={Benchmarking ortholog identification methods using functional genomics data},
  author={Tim Hulsen and M. Huynen and J. de Vlieg and P. Groenen},
  journal={Genome Biology},
  pages={R31 - R31}
  • Tim Hulsen, M. Huynen, +1 author P. Groenen
  • Published 2005
  • Medicine, Biology, Physics
  • Genome Biology
  • BackgroundThe transfer of functional annotations from model organism proteins to human proteins is one of the main applications of comparative genomics. Various methods are used to analyze cross-species orthologous relationships according to an operational definition of orthology. Often the definition of orthology is incorrectly interpreted as a prediction of proteins that are functionally equivalent across species, while in fact it only defines the existence of a common ancestor for a gene in… CONTINUE READING
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