Benchmarking ortholog identification methods using functional genomics data

@article{Hulsen2006BenchmarkingOI,
  title={Benchmarking ortholog identification methods using functional genomics data},
  author={Tim Hulsen and Martijn A. Huynen and Jacob de Vlieg and Peter M. A. Groenen},
  journal={Genome Biology},
  year={2006},
  volume={7},
  pages={R31 - R31}
}
BackgroundThe transfer of functional annotations from model organism proteins to human proteins is one of the main applications of comparative genomics. Various methods are used to analyze cross-species orthologous relationships according to an operational definition of orthology. Often the definition of orthology is incorrectly interpreted as a prediction of proteins that are functionally equivalent across species, while in fact it only defines the existence of a common ancestor for a gene in… 

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