Benchmarking B cell epitope prediction: underperformance of existing methods.

  title={Benchmarking B cell epitope prediction: underperformance of existing methods.},
  author={Martin J. Blythe and Darren R. Flower},
  journal={Protein science : a publication of the Protein Society},
  volume={14 1},
Sequence profiling is used routinely to predict the location of B-cell epitopes. In the postgenomic era, the need for reliable epitope prediction is clear. We assessed 484 amino acid propensity scales in combination with ranges of plotting parameters to examine exhaustively the correlation of peaks and epitope location within 50 proteins mapped for polyclonal responses. After examining more than 10(6) combinations, we found that even the best set of scales and parameters performed only… CONTINUE READING
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