Benchmark dose analysis of developmental toxicity in rats exposed to boric acid.

  title={Benchmark dose analysis of developmental toxicity in rats exposed to boric acid.},
  author={Bruce C. Allen and Philip L. Strong and Catherine J. Price and Susan A. Hubbard and George P. Daston},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={32 2},
Developmental toxicity risk assessment has typically relied on the estimation of reference doses or reference concentrations based on the use of no-observed-adverse-effect levels (NOAELs) divided by uncertainty factors. The benchmark dose (BMD) approach has been proposed as an alternative basis for reference value calculations. In this analysis of the developmental toxicity observed in rats exposed to boric acid in their diet, BMD analyses have been conducted using two existing studies. By… CONTINUE READING


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