Benchmark calculations in risk assessment using continuous dose-response information: the influence of variance and the determination of a cut-off value.

@article{Sand2003BenchmarkCI,
  title={Benchmark calculations in risk assessment using continuous dose-response information: the influence of variance and the determination of a cut-off value.},
  author={Salomon J Sand and Dietrich von Rosen and Agneta Falk Filipsson},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={2003},
  volume={23 5},
  pages={1059-68}
}
A benchmark dose (BMD) is the dose of a chemical that corresponds to a predetermined increase in the response (the benchmark response, BMR) of a health effect. In this article, a method (the hybrid approach) for benchmark calculations from continuous dose-response information is investigated. In the formulation of the methodology, a cut-off value for an adverse health effect has to be determined. It is shown that the influence of variance on the hybrid model depends on the choice of… CONTINUE READING

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