Bench-to-bedside review: Toll-like receptors and their role in septic shock

  title={Bench-to-bedside review: Toll-like receptors and their role in septic shock},
  author={Steven M. Opal and Christian E. Huber},
  journal={Critical Care},
  pages={125 - 136}
The Toll-like receptors (TLRs) are essential transmembrane signaling receptors of the innate immune system that alert the host to the presence of a microbial invader. The recent discovery of the TLRs has rapidly expanded our knowledge of molecular events that initiate host-pathogen interactions. These functional attributes of the cellular receptors provide insights into the nature of pattern recognition receptors that activate the human antimicrobial defense systems. The fundamental… CONTINUE READING


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