Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians

  title={Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians},
  author={Ana Laura Huerta-Alardin and Joseph Varon and Paul Ellis Marik},
  journal={Critical Care},
  pages={158 - 169}
Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea… 
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Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.
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  • 2000
The sometimes subtle manifestations of exertional (non-traumatic) rhabdomyolysis make it mandatory that the health care team is able to recognize the signs and symptoms and understand the pathophysiology for prompt treatment and referral.
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Understanding the underlying pathophysiology of rhabdomyolysis may allow for the future development of improved therapeutic modalities and improve the acute medical care of the patient with electrical injury.
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    Medical toxicology and adverse drug experience
  • 1989
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  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1996
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