Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?

@article{Pea2009BenchtobedsideRA,
  title={Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?},
  author={Federico Pea and Pierluigi Viale},
  journal={Critical Care},
  year={2009},
  volume={13},
  pages={214 - 214}
}
Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean prompt achievement and maintenance of optimal exposure at the infection site with broad-spectrum antimicrobial agents administered in a timely manner. Once the causative pathogens have been identified and tested for in vitro susceptibility, subsequent de-escalation of antimicrobial therapy should be applied whenever feasible. The goal of appropriate antibiotic therapy must be pursued resolutely and with… CONTINUE READING