Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.

@article{Benjamin2008BenchTB,
  title={Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.},
  author={Jacqueline M. Benjamin and Wallace J. Nelson},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 1},
  pages={53-64}
}
The cadherin/catenin complex, comprised of E-cadherin, beta-catenin and alpha-catenin, is essential for initiating cell-cell adhesion, establishing cellular polarity and maintaining tissue organization. Disruption or loss of the cadherin/catenin complex is common in cancer. As the primary cell-cell adhesion protein in epithelial cells, E-cadherin has long been studied in cancer progression. Similarly, additional roles for beta-catenin in the Wnt signaling pathway has led to many studies of the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…