Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.

  title={Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.},
  author={Kenneth A. Jamerson and Michael D Weber and George L Bakris and Bj{\"o}rn Dahl{\"o}f and Bertram Pitt and Victor Shi and Allen Hester and Jitendra Gupte and Marjorie R Gatlin and Eric Jose Velazquez},
  journal={The New England journal of medicine},
  volume={359 23},
BACKGROUND The optimal combination drug therapy for hypertension is not established, although current U.S. guidelines recommend inclusion of a diuretic. We hypothesized that treatment with the combination of an angiotensin-converting-enzyme (ACE) inhibitor and a dihydropyridine calcium-channel blocker would be more effective in reducing the rate of cardiovascular events than treatment with an ACE inhibitor plus a thiazide diuretic. METHODS In a randomized, double-blind trial, we assigned 11… CONTINUE READING
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