Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

@article{Godlewski2015BelongingTA,
  title={Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.},
  author={Jakub Godlewski and Anna M. Krichevsky and Mark D. Johnson and E Antonio Chiocca and Agnieszka Bronisz},
  journal={Neuro-oncology},
  year={2015},
  volume={17 5},
  pages={652-62}
}
The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed… CONTINUE READING