Bell-shaped curves for prostaglandin-induced modulation of adenylate cyclase: two mutually opposing effects.

@article{Accomazzo2002BellshapedCF,
  title={Bell-shaped curves for prostaglandin-induced modulation of adenylate cyclase: two mutually opposing effects.},
  author={Maria Rosa Accomazzo and Sarah Cattaneo and Simonetta Nicosia and Gianenrico Rovati},
  journal={European journal of pharmacology},
  year={2002},
  volume={454 2-3},
  pages={107-14}
}
Each of the natural prostanoid is at least one order of magnitude more potent for its specific receptor (DP, EP, FP, IP and TP) than any of the other prostanoids. However, they are able to interact also with one or more of the other classes of prostanoid receptors. The concentration-response curves for modulation of adenylate cyclase activity in rabbit mesenteric artery smooth muscle cells by different prostaglandins are not always monotonic, i.e. simple sigmoidal curves in logarithmic scale… CONTINUE READING

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