Bell's Palsy and Herpes Simplex Virus: Fact or Mystery?

@article{Linder2005BellsPA,
  title={Bell's Palsy and Herpes Simplex Virus: Fact or Mystery?},
  author={Thomas Linder and Walter Bossart and Daniel J Bodmer},
  journal={Otology \& Neurotology},
  year={2005},
  volume={26},
  pages={109-113}
}
Hypothesis and Background In recent years, progress has been made in the understanding of Bell's palsy, the most common form of acute facial weakness. Herpes simplex virus (HSV) reactivation within the geniculate ganglion with subsequent inflammation and entrapment of the nerve at the meatal foramen has been proposed to be the pathogenetic mechanism. We challenged its accuracy by analyzing our own data on the presence of viral genomic DNA of HSV-1 and 2, human herpes virus (HHV)-6A/B, as well… Expand
HERPES SIMPLEX VIRUS IN SALIVA OF PATIENTS WITH BELL'S PALSY
TLDR
Investigating the presence of DNA of HSV in the saliva of 26 patients with Bells palsy in first and second weeks of disorder compared to normal population who were matched in sex, age, as well as history of diabetes mellitus, hypertension and labial herpes found no relationship between Bell's palsy or its severity and positive PCR for HSV was not detected. Expand
Herpes Virus and Ménière’s Disease
TLDR
Analysis of vestibular ganglia from patients with intractable classic Ménière’s disease for the presence or absence of DNA from three neurotropic viruses herpes simplex virus 1 and 2 and varicella zoster virus (VZV) found genomic DNA of these viruses was unable to find in patients with definite MD and disabling vertigo, who underwent Vestibular neurectomy. Expand
Association of herpes simplex virus infection and Bell's palsy.
TLDR
The study suggests that a relationship exists between HSV infection and Bell's palsy and the information might prove helpful in hastening the recovery by modifying management guidelines in view of the results of this study. Expand
Varicella zoster virus in Bell's palsy: a prospective study.
TLDR
Varicella zoster virus was detected in 1.7% of saliva samples from patients with Bell's palsy, using PCR, and the virus was not identified in saliva sample from the controls. Expand
Early collection of saliva specimens from Bell's palsy patients: Quantitative analysis of HHV‐6, HSV‐1, and VZV
TLDR
Findings call into question the role of HSV‐1 and VZV in the etiology of Bell's palsy, and suggest that HHV‐6 may be involved in the development of the disease or that the underlying disease mechanism might predispose patients to HHv‐6 reactivation. Expand
Search for Herpesviruses in cerebrospinal fluid of facial palsy patients by PCR
TLDR
Herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) DNA were not detected in the cerebrospinal fluid of patients with acute idiopathic peripheral facial palsy (Bell's palsy), indicating either the absence of these viruses or the presence of technical shortcomings. Expand
Bell's Palsy - Medical Treatment and Influence of Prognostic Factors
TLDR
Prednisolone treatment in Bell’s palsy is recommended for use in adult patients regardless of severity of palsy and age, and should be started as early as possible, as long as no contraindications for steroid treatment is present. Expand
The possible Role of HHV-6, HHV-7 and EBV in Patient with Bell's palsy
TLDR
Human herpes viruses 6 and 7 and EBV could play an important role in the development of BP and HHV-6 might have a neuro-pathological effect in severe cases of BP, howeverHHV-7 doesn't seem to play a roles in the pathogenesis of the disease. Expand
A Cell Culture Model of Facial Palsy Resulting From Reactivation of Latent Herpes Simplex Type 1
  • M. Kuhn, Shruti D Nayak, +5 authors P. Roehm
  • Medicine
  • Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2012
TLDR
It is shown that cultured GGNs can be latently infected with HSV-1, and HSv-1 in these latent infected neurons can be reactivated using TSA, yielding infectious virus. Expand
Bell's palsy and vestibular neuronitis.
TLDR
Bell's palsy and vestibular neuritis are uncommon conditions but can be the cause of significant acute neurologic disability, with the most frequent being idiopathic and the etiology frequently presumed to be inflammatory and potentially related to reactivation of latent viral infection. Expand
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