Belimumab for the treatment of systemic lupus erythematosus

@article{Jordan2015BelimumabFT,
  title={Belimumab for the treatment of systemic lupus erythematosus},
  author={N Jordan and David D'cruz},
  journal={Expert Review of Clinical Immunology},
  year={2015},
  volume={11},
  pages={195 - 204}
}
  • N. Jordan, D. D'cruz
  • Published 16 January 2015
  • Medicine, Biology
  • Expert Review of Clinical Immunology
Given their pivotal role in autoantibody production, B-cells have become an attractive therapeutic target in systemic lupus erythematosus (SLE). Belimumab, a fully human monoclonal antibody against B lymphocyte stimulator (BLyS), a B-cell survival factor, was licensed in 2011 for the treatment of autoantibody-positive SLE. The BLISS-52 and BLISS-76 Phase III trials successfully demonstrated that belimumab (10 mg/kg) with standard therapy significantly decreased disease activity in SLE patients… 

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References

SHOWING 1-10 OF 60 REFERENCES

Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus

TLDR
Belimumab was well tolerated and reduced peripheral B-cell levels in SLE patients and these data support further studies of belimumab in autoimmune disorders.

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials

TLDR
Belimumab treatment improved overall SLE disease activity in the most common musculoskeletal and mucocutaneous organ domains and less worsening occurred in the haematological, immunological and renal domains.

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab.

TLDR
Rituximab therapy appears to be safe for the treatment of SLE and holds significant therapeutic promise, at least for the majority of patients experiencing profound B cell depletion.

An open study of B lymphocyte depletion in systemic lupus erythematosus.

TLDR
This study provides sufficient evidence for the safety and possible efficacy of B lymphocyte depletion therapy in SLE to justify a formal controlled trial.

B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients.

TLDR
In this open study of patients who had failed conventional immunosuppressive therapy, considerable utility in the use of B-cell depletion has been demonstrated and data provide strong support for the performance of a full double blind control trial.

Novel evidence-based systemic lupus erythematosus responder index.

TLDR
This evidence-based evaluation of a large randomized, placebo-controlled trial in SLE resulted in the ability to define a robust responder index based on improvement in disease activity without worsening the overall condition or the development of significant disease activity in new organ systems.

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus.

TLDR
Belimumab plus standard therapy significantly improved SRI response rate, reduced SLE disease activity and severe flares, and was generally well tolerated in SLE.

A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab

TLDR
Based on the patient's clinically mild SLE and the timing of symptom onset, belimumab likely played a key role in the development of PML and careful monitoring for this potentially fatal adverse effect is warranted.

B cell depletion therapy in systemic lupus erythematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response.

TLDR
Patients with SLE with an expanded autoantibody profile and raised BLyS levels at baseline had shorter clinical responses to BCDT, which suggests that treatment regimens beyond B CDT may be necessary to induce long-lasting clinical remissions in these individuals.
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