Believe it or not: how much can we rely on published data on potential drug targets?

@article{Prinz2011BelieveIO,
  title={Believe it or not: how much can we rely on published data on potential drug targets?},
  author={Florian Prinz and Thomas Schlange and Khusru Asadullah},
  journal={Nature Reviews Drug Discovery},
  year={2011},
  volume={10},
  pages={712-712}
}
1. This indicates the limitations of the predictivity of disease models and also that the validity of the targets being investigated is frequently questionable, which is a crucial issue to address if success rates in clinical trials are to be improved. Candidate drug targets in industry are derived from various sources, including inhouse target identification campaigns, inlicensing and public sourcing, in particular based on reports published in the literature and presented at conferences… CONTINUE READING

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