Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage.

@article{Wohlbold2009BehindTW,
  title={Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage.},
  author={Lara Wohlbold and Robert P Fisher},
  journal={DNA repair},
  year={2009},
  volume={8 9},
  pages={1018-24}
}
Cell division and the response to genotoxic stress are intimately connected in eukaryotes, for example, by checkpoint pathways that signal the presence of DNA damage or its ongoing repair to the cell cycle machinery, leading to reversible arrest or apoptosis. Recent studies reveal another connection: the cyclin-dependent kinases (CDKs) that govern both DNA synthesis (S) phase and mitosis directly coordinate DNA repair processes with progression through the cell cycle. In both mammalian cells… CONTINUE READING

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