Behind the Scenes of Gene Expression

  title={Behind the Scenes of Gene Expression},
  author={Elizabeth Pennisi},
  pages={1064 - 1067}
As the units of DNA that define the proteins needed for life, genes have played biology9s center stage for decades. But work over the past few years shows that gene expression is not determined solely by the DNA code itself but by an assortment of proteins and, sometimes, RNAs that tell the genes when and where to turn on or off. Such epigenetic phenomena orchestrate the many changes through which a single fertilized egg cell turns into a complex organism. And throughout life, they enable cells… 
Echoes from the past – are we still in an RNP world?
  • J. Brosius
  • Biology
    Cytogenetic and Genome Research
  • 2005
Availability of the human genome sequence and those of other species is unmeasured in their value for a comprehensive understanding of the architecture, function and evolution of genomes and cells.
Proteins, the chaperone function and heredity
The evidence I here present of a crucial role for molecular chaperones in the folding of nascent proteins, as well as in DNA duplication, RNA folding and gene control, suggests that the family of proteins acting as molecular chapers provides information that is complementary to that stored in the nucleic acids, and equally important.
The Control of Expression of the α-Globin Gene Cluster
In this article, the research on the control of expression of the α-globin gene cluster is summarized with respect to the α—major regulatory element (α-MRE): HS-40, the tissue-specific and developmental control of its expression, and its chromosomal environment.
Epigenetics: Connecting Environment and Genotype to Phenotype and Disease
The challenge in oral biology will be to understand the mechanisms that modify MVPs in oral tissues and to identify those epigenetic patterns that modify disease pathogenesis or responses to therapy.
Epigenetics: A Challenge for Genetics, Evolution, and Development?
It is argued that differences in how one relates the genome to its surrounding contexts leads to diverse interpretations of the term epigenetics, and a paradigmatic shift has taken place in biology from the abandonment of a gene‐centric position on to the present.
Epigenetics and the Environment
It is proposed that DNA hypo‐ and hypermethylation are both important in the development of arsenic‐induced cancers, and heightened awareness by toxicologists of the importance of epigenetics in normal human development and in carcinogenesis should lead to the identification of other toxicants that manifest their effects via epigenetic mechanisms.
Epigenetics and Language: The Minimalist Program, Connectionism and Biology
It is agreed that inclusion of epigenetic processes in linguists' theories of language development is important if linguists desire unification with biology, and connectionism is the superior paradigm for researchers interested in unification between biology and linguistics.
Images of the Genome: From Public Debates to Biology, and Back, and Forth
This essay starts from the assumption that metaphors play a large role in the understanding of scientific concepts, and the question arises which images it provides in association with reaction norms.
Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle
These studies indicate that HG exposure induces NF-κB recruitment and histone modification at the Prep1 5′ region, thereby enhancing the transcription of Prep1 and repressing that of Glut4.