Behavioural toxicity of antidepressants with particular reference to moclobemide

  title={Behavioural toxicity of antidepressants with particular reference to moclobemide},
  author={Ian Hindmarch and John S. Kerr},
The clinical decision to use a particular antidepressant should be made with reference to the behavioural toxicity profiles of substances in current use. Antidepressants can be cardiotoxic, proconvulsant, able to cause weight gain and sleep disturbance, and also impair psychological functions necessary for everyday living. Behavioural toxicity (reduction in psychomotor activity or cognitive ability) tends to augment levels of psychomotor and cognitive retardation; meta-analysis of controlled… Expand
Comparison of Effect of Antidepressants on Psychomotor Functions
Sertraline significantly improves psychomotor function as compared to desvenlafaxine while fluoxetine impairs, and Hamilton rating score improved at the end of 3 months treatment asCompared to baseline. Expand
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  • U. Bonnet
  • Psychology, Medicine
  • CNS drug reviews
  • 2003
Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) and has been extensively evaluated in the treatment of a wide spectrum of depressive disorders and less extensively studied inExpand
Experimental anxiety and antidepressant drugs: the effects of moclobemide, a selective reversible MAO-A inhibitor, fluoxetine and imipramine in mice
  • L. Angelis
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  • Naunyn-Schmiedeberg's Archives of Pharmacology
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  • J. Tiller
  • Medicine
  • Acta psychiatrica Scandinavica. Supplementum
  • 1990
Moclobemide appears to be an antidepressant with few psychomotor effects and minimal alcohol potentiation and may reduce some alcohol impairment. Expand
Evaluation and comparison of the interaction between alcohol and moclobemide or clomipramine in healthy subjects
Moclobemide did not show anticholinergic properties and produced fewer adverse effects than clomipramine in interaction with alcohol and seemed to diminish alcohol-induced memory impairment in one of the memory tests used. Expand
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Comparison of the SRRS and other rating scale scores demonstrates that retardation is related to depression severity and therapeutic change and is a good criterion for prediction of therapeutic effect. Expand
A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour.
Temazepam showed very much the same effects as they are known from conventional 1,4-benzodiazepines except for its lack of impairment in early morning behavior following night time medication. Expand
Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.
Neither moclobemide nor toloxatone altered memory function, vigilance, subjective feelings or sleep characteristics of the subjects. Expand
The effects of clobazam on critical flicker fusion threshold and symptomatology during the menstrual cycle
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  • I. Hindmarch
  • Psychology, Medicine
  • British journal of clinical pharmacology
  • 1980
A cursory review of the literature reveals that the techniques used to assess psychomotor functions are diverse, often complex, frequently insensitive to drug induced changes and sometimesExpand