Behavioural stress facilitates the induction of long-term depression in the hippocampus

@article{Xu1997BehaviouralSF,
  title={Behavioural stress facilitates the induction of long-term depression in the hippocampus},
  author={Lin Huao Xu and Roger Anwyl and Michael J. Rowan},
  journal={Nature},
  year={1997},
  volume={387},
  pages={497-500}
}
The induction of activity-dependent persistent increases in synap-tic efficacy, such as long-term potentiation (LTP), is inhibited by behavioural stress1,2. The question arises whether stress also affects the ability to induce persistent decreases in synaptic efficacy, such as long-term depression (LTD)3–5. We now report that the induction of stable homosynaptic LTD in the CA1 area of the hippocampus of awake adult rats is facilitated, rather than inhibited, by exposure to mild naturalistic… CONTINUE READING
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