Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice.

@article{Zapata2003BehaviouralSA,
  title={Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice.},
  author={Agustin Zapata and Vladimir I. Chefer and Robert Ator and Toni Shaun Shippenberg and Beatriz A. Rocha},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 3},
  pages={590-6}
}
The behavioural effects of cocaine are enhanced in animals with a prior history of repeated cocaine administration. This phenomenon, referred to as sensitization, is also associated with an increase in cocaine-evoked extracellular dopamine levels in the nucleus accumbens. Behavioural and neurochemical sensitization has been demonstrated in rats with a prior history of cocaine self-administration and in those that had received experimenter-administered cocaine. Although it is clear that the… CONTINUE READING

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