Behavioural sensitization after repeated exposure to Δ9-tetrahydrocannabinol and cross-sensitization with morphine

@article{Cadoni2001BehaviouralSA,
  title={Behavioural sensitization after repeated exposure to $\Delta$9-tetrahydrocannabinol and cross-sensitization with morphine},
  author={Cristina Cadoni and Augusta Pisanu and Marcello Solinas and Elio Acquas and Gaetano di Chiara},
  journal={Psychopharmacology},
  year={2001},
  volume={158},
  pages={259-266}
}
Abstract. Rationale: Repeated exposure to several drugs of abuse has been reported to induce behavioural sensitization. So far no evidence has been provided that such a phenomenon also applies to cannabinoids. Objectives: In this study we investigated if repeated exposure to Δ9-tetrahydrocannabinol (Δ9-THC) induces behavioural sensitization. In addition we tested the possibility of cross-sensitization between Δ9-THC and morphine. Methods: Male Sprague-Dawley rats were administered for 3 days… 
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Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not
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