Behavioural evidence for cholecystokinin-dopamine D1 receptor interactions in the rat.

@article{Kampen1996BehaviouralEF,
  title={Behavioural evidence for cholecystokinin-dopamine D1 receptor interactions in the rat.},
  author={Jackalina M Van Kampen and H. Frydryszak and A. Jon Stoessl},
  journal={European journal of pharmacology},
  year={1996},
  volume={298 1},
  pages={
          7-15
        }
}
The effects of cholecystokinin (CCK) on behavioural responses to the dopamine D1 receptor agonist (+/- )SKF 38393 ((+/- )-2,3,4,5-tetrahydro-7,8- dihydroxy-1-phenyl-1H-3-benzazepine HCl) were studied in the rat. SKF 38393 (5 mg/kg s.c.) induced stereotyped grooming and vacuous chewing movements. Both responses were inhibited by CCK-8S (10-50 micrograms/kg i.p.), but the preferential CCKB receptor agonist CCK-4 (20-100 micrograms/kg i.p.) attenuated SKF 38393-induced grooming only. Suppression… CONTINUE READING
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