Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms.

@article{Schoenfelder2012BehaviouralCO,
  title={Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms.},
  author={Y Schoenfelder and Christoph Hiemke and Ulrich Schmitt},
  journal={Journal of neuroendocrinology},
  year={2012},
  volume={24 5},
  pages={809-17}
}
P-glycoprotein (P-gp), an efflux transporter localised in the blood-brain barrier, limits the access of multiple xenobiotics to the central nervous system. Whether it is also implemented in the transport of the endogenous glucocorticoid corticosterone is a matter of debate. The P-gp knockout mouse model [abcb1a/b (-/-)] has been shown to differ in the functioning of the hypothalamic-pituitary adrenal (HPA) axis. In the present study, we investigated the behaviour of abcb1a/b (-/-) and wild-type… CONTINUE READING
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