Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety.

@article{Wang2007BehaviouralAN,
  title={Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety.},
  author={Dayong Wang and Yukihiro Noda and Hiroko Tsunekawa and Yuan Zhou and M. Miyazaki and Koji Senzaki and Toshitaka Nabeshima},
  journal={Behavioural brain research},
  year={2007},
  volume={178 2},
  pages={262-73}
}
In order to probe the nature and validity of olfactory bulbectomized (OB) rats as a model of depression, we reevaluated their behavioural and neurochemical deficits in relation to the symptoms and neurochemical abnormalities of depression using our protocols, which distinguish anhedonia-resembling behaviour in sexual behavioural test, the hippocampus (Hip)-dependent long-term memory and anxiety-resembling behaviour specially. Besides exploratory hyperactivity in response to a novel… CONTINUE READING