Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression.

@article{Redmond1997BehaviouralAN,
  title={Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression.},
  author={Ann M. Redmond and John P. J. Kelly and Brian E. Leonard},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={58 2},
  pages={355-9}
}
The activity of dizocilpine (MK-801; 0.1 and 0.3 mg/kg) administered once daily intraperitoneally (I.P.) was assessed in the olfactory bulbectomized rat model of depression. Olfactory bulbectomy (OB) is associated with a variety of behavioural abnormalities, such as hyperactivity in the "open field" test. Previous studies have shown that chronic administration of antidepressants can reverse this behavioural deficit. In the present study, chronic treatment with 0.1 and 0.3 mg/kg of dizocilpine… CONTINUE READING

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