Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains

@article{Bekris2005BehaviouralAN,
  title={Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains},
  author={Stathis Bekris and Katerina Antoniou and Spyros Daskas and Zeta Papadopoulou-Daifoti},
  journal={Behavioural Brain Research},
  year={2005},
  volume={161},
  pages={45-59}
}
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that resembles some of the symptoms of endogenous depression in humans. In the present study, CMS-induced behavioural responses along with neurochemical alterations in dopaminergic and serotonergic function in prefrontal cortex, striatum, hypothalamus and hippocampus were examined following treatment with imipramine in Wistar and Sprague-Dawley rats. The CMS procedure lasted 7 weeks in total. Once per week, a… CONTINUE READING

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