Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.

@article{Tamburella2013BehaviouralAN,
  title={Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.},
  author={Alessandra Tamburella and Gian Marco Leggio and Vincenzo Micale and Andrea Navarria and Claudio Bucolo and Valentina Cicirata and Filippo Drago and Salvatore Salomone},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 4},
  pages={
          813-23
        }
}
These experiments were undertaken to assess the mechanisms underlying the antidepressant-like effects of the neurokinin-2 (NK(2)) receptor antagonist saredutant (SR48968) in rats tested in the forced swim test (FST), by analysing hippocampal brain-derived neurotrophic factor (BDNF) and plasma corticosterone [as index of hypothalamic-pituitary-adrenal (HPA) axis activity]. Male Wistar rats received three intraperitoneal injections over 24 h of vehicle, saredutant (5 mg/kg), citalopram (15 mg/kg… CONTINUE READING
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