Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance

Abstract

Previous studies have demonstrated that prolonged morphine treatment in vivo induces the translocation of delta opioid receptors (deltaORs) from intracellular compartments to neuronal plasma membranes and this trafficking event is correlated with an increased functional competence of the receptor. The mechanism underlying this phenomenon is unknown; however… (More)

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