Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice.

@article{Dowie2010BehaviouralAM,
  title={Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice.},
  author={Megan J. Dowie and Monique L. Howard and Louise FB Nicholson and Richard Lewis Maxwell Faull and Anthony J Hannan and Michelle Glass},
  journal={Neuroscience},
  year={2010},
  volume={170 1},
  pages={324-36}
}
Early loss of CB1 receptors is a hallmark of human Huntington's disease. Data from rodent studies suggest that preservation and activation of CB1 receptors may be protective against disease progression. R6/1 transgenic mice are considered to be a model of early pathogenic changes in Huntington's disease. We have shown previously that levels of CB1 in R6/1 mice prior to the onset of motor symptoms (12 weeks of age) remain high enough to justify commencement of cannabinoid drug treatment. Eight… CONTINUE READING

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