Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice

@article{Oliva2003BehaviouralAG,
  title={Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice},
  author={Jos{\'e} M. Oliva and Sergio Ortiz and Tom{\'a}s Palomo and Jorge Manzanares},
  journal={Journal of Neurochemistry},
  year={2003},
  volume={85}
}
This study examined behavioural signs that occur during tolerance development to cannabinoid treatment and hormonal and gene expression alterations induced by spontaneous cannabinoid withdrawal in mice. Tolerance to CP‐55,940 treatment developed for hypothermia, ambulatory and exploratory locomotor activity. Cessation of cannabinoid treatment resulted in a behavioural withdrawal syndrome characterized by a pronounced increase in ambulatory activity and rearings. Corticosterone plasma… 

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