Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor.

@article{Bristow1991BehaviouralAB,
  title={Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor.},
  author={Linda J. Bristow and L Baucutt and Lieselotte Thorn and Peter H. Hutson and Alistair Noble and Meinrad Joachim Beer and Derek N. Middlemiss and Mark D. Tricklebank},
  journal={European journal of pharmacology},
  year={1991},
  volume={204 1},
  pages={21-8}
}
The behavioural and biochemical profile of the sigma ligand and putative antipsychotic agent, BMY 14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2- pyrimidinyl)-1-piperazine butanol) has been determined in the mouse and rat. In mice, pretreatment with BMY 14802 attenuated both amphetamine-induced hyperactivity and conditioned avoidance responding, consistent with its previously reported antipsychotic potential. In common with 5-HT1A receptor agonists or partial agonists, BMY 14802 induced (a) a dose… CONTINUE READING