Behavioural and antinociceptive effects of intrathecally injected substance P analogues in mice.

Abstract

The antinociceptive effects and antagonism of substance P (SP)-induced behaviour were examined after intrathecal injections in mice. When coadministered with SP, the SP analogues attenuated the SP-induced behaviour to various extents with [D-Arg1,D-Pro2,4,D-PHe7,D-His9]SP as the most potent antagonist. Physalaemin and eledoisin brought about a SP-like… (More)

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