Behavioural and Morphological Outcome of Mild Cortical Contusion Trauma of the Rat Brain: Influence of NMDA-Receptor Blockade

 The authors studied the effect of a mild cortical contusion to the rat brain on behavioural and morphological outcome and the influence of NMDA-receptor blockade (MK-801, 0.5 mg/kg i.v. 30 min prior to trauma). Spontaneous motor activity was assessed 16–18 days post trauma. Saline treated traumatised rats showed a significant (p<0.01) hyperactive behaviour… CONTINUE READING