Behaviour of doxycycline in the tissues.

  title={Behaviour of doxycycline in the tissues.},
  author={Pierre Blanchard and M. Rudhardt and J-E. Fabre},
  volume={21 Suppl 1},
Little is known about the behaviour of antibiotics in the tissues. To investigate this problem, rats were sacrificed in groups of six, 1, 2, 4, 6, 8, 12 and 18 h after an intraperitoneal injection of 10 mg doxycycline/kg body weight. The antibiotic levels were determined in the nine major organs and in the serum by a microbiological method. One hour after injection, the doxycycline concentrations in all the tissues were already higher than the serum concentrations. After 4 h, the concentration… CONTINUE READING