Behaviour of cats after intraventricular injections of eserine and DFP

@article{Feldberg1954BehaviourOC,
  title={Behaviour of cats after intraventricular injections of eserine and DFP},
  author={W. S. Feldberg and STEPHEN L. Sherwood},
  journal={The Journal of Physiology},
  year={1954},
  volume={125}
}
In a previous paper we have described the effects of a number of drugs injected into the unanaesthetized cat through a cannula permanently implanted into the lateral cerebral ventricle (Feldberg & Sherwood, 1954). The present paper records the effects of the anticholinesterases eserine and diisopropylfluorophosphonate (DFP) administered by the same route. A few experiments were also made with large doses of acetylcholine. 

Injections of bulbocapnine into the cerebral ventricles of cats.

Recently it was found (Feldberg and Sherwood, 1954b) that the anticholinesterases dyflos (DFP) and eserine, when given to cats by the intraventricular route, produce a condition with many of the

Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs

1. In dogs anaesthetized with pentobarbitone sodium an injection of adrenaline or noradrenaline into the cerebral ventricles through a cannula implanted into the left lateral ventricle caused a fall

Action of acetylcholine and carbachol when injected into the cerebral ventricles

  • E. Rutman
  • Biology, Medicine
    Bulletin of Experimental Biology and Medicine
  • 2004
Acetylcholine and carbocholine administered into the lateral ventricle of the rabbit brain caused a distinct, stable picture of activation of the EEG, excitation and in a number of cases exophthalmos and bradycardia.

Intracarotid injections and infusions of cholinomimetic drugs and their antagonists in conscious dogs.

No studies are available, however, on the effects of intracarotid injections of acetylcholine in conscious animals, which would expose the brain to a higher coneentration of the drug than the rest of the body.

SLEEP INDUCED BY DRUGS INJECTED INTO THE INFERIOR HORN OF THE LATERAL CEREBRAL VENTRICLE IN DOGS

In unanaesthetized dogs, cholinomimetic drugs and their antagonists were injected into the inferior horn of the left lateral cerebral ventricle and the effects on EEG and behaviour were recorded and compared with the effects of the same doses given into the body of the right lateral Ventricle a little behind the foramen of Monro.

Pharmacological properties of cholinoceptive neurones in the medulla and pons of the cat

Iontophoretic application of acetylcholine to neurones in the medulla and pons of the unanaesthetized decerebrate cat excited 35·5% and inhibited 22% of lower brain stem neurones, since most penetrations were made medially.

Pharmacological evaluation of seizures induced by electrical stimulation of the hippocampus.

A method to induce minimal seizures in unrestrained rats via bipolar electrodes implanted in the right dorsal hippocampus has been described. The threshold for such seizures is reproducible, stable

Antagonism between physostigmine and atropine on the behavior of the pigeon

  • G. Vaillant
  • Biology, Psychology
    Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
  • 2004
The findings support the general supposition that suppression of behavior by physostigmine is in part mediated by muscarinic receptors in the central nervous system.
...

References

SHOWING 1-10 OF 21 REFERENCES

EFFECT OF CERTAIN CHOLINE DERIVATIVES ON ELECTRICAL ACTIVITY OF THE CORTEX

The present report deals with the results and interpretation of a series of experiments on the effect of three choline derivatives on the electrical activity of the cerebral cortex of cats, using cats anesthetized with intraperitoneal injections of dial.

Experimental study of itch stimuli in animals.

Recent observations have made it possible to use animals for experiments with pruritus and this work deals with a sustained type of itch paroxysm which tends to fluctuate in intensity between peaks separated by periods of exhaustion.

Shifting of cations in the cerebrospinal fluid as a cause of pruritus.

The following series of experiments were performed to attempt to further elucidate the role of potassium and potassium-like salts in pruritus.

Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation.

  • J. Broadbent
  • Medicine
    British journal of pharmacology and chemotherapy
  • 1953
The concept of histamine as a chemical mediator of the itch sensation is not new and all the features of an urticarial lesion-weal, flare, and itching)-could be reproduced by pricking histamine into the skin.

THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS

DFP dissolved in peanut oil was administered by intramuscular injection to 17 cases of schizophrenia and 9 cases of manic depressive psychosis to determine its influence, if any, on the mental state of these cases, and to observe whether the physical and EEG changes produced differed from those previously reported in normal subjects.

Injections of drugs into the lateral ventricle of the cat

The method formerly used for intraventricular injections in unanaesthetized animals has the following drawbacks: the animals are physically restrained; fear, pain and other defence reactions may overshadow or modify the drug effect; and there must always remain a certain doubt whether injury of the brain substance has occurred and is responsible for the observed effects.

A permanent cannula for intraventricular injections in cats.

Intraventricular medication in catatonic stupor.

Experimentelle Untersuchungen uber den Juckreflex am Tier . 2 te Mitteilung . Auslosen heftiger Juckanfalle bei der Katze durch introcisternale Injektionen von Morphium und einige seiner Derivate

  • Arch . exp . Path . Pharmak .
  • 1938

Lichen plan et ponction lombaire

  • Bull . Soc . franc Derm . Syph .
  • 1927