Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.

@article{Rodgers1998BehaviorallySE,
  title={Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.},
  author={R John Rodgers and N. J. T. Johnson},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={59 1},
  pages={221-32}
}
A number of A-ring-reduced metabolites of deoxycorticosterone and progesterone, known to exert agonist activity at the GABA(A) receptor complex, have been reported to reduce anxiety-related behavior in rodents. In the present study, the behavioral selectivity of these effects was assessed in an ethological version of the mouse elevated plus-maze paradigm. Anxiolytic-like profiles, characterised principally by reductions in open arm avoidance measures, were observed following systemic treatment… CONTINUE READING

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